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Work package 07

Implantable markers for image guided radiotherapy

Objectives
Research projects in this work package are aimed at developing and investigating the use of fiducial markers for radiotherapy. Three different markers will be investigated. Lipiodol, a X-ray contrast media to be injected into the sub mucosa in bladder, a radiofrequent marker coil for definition of radioactive source catheters in MRI and a Ni-Ti memory shape stent which can inserted in various organs (prostate and lung) trough natural body orifices and used as X-ray fiducial marker.
Description of work
Task 7.1. Design phase (Ni-Ti stent). Include laboratory work and studies using mock-up silicon or cadaver organs. Various tests have to be conducted to decide on design, deployment and removal of a potential new stent.
Task 7.2. Pre Clinical test (radiofrequent marker and Ni-Ti stent). Include animal studies of insertion and removal of a potential new stent. Animal studies are important to study potential hazardous side effects from insertion, long term implantation and removal of the new stent
Task 7.3. (Clinical feasibility studies, Lipiodol, radiofrequent marker and Ni-Ti stent). Feasibility studies aimed at investigating specific endpoints. Such as migration of the marker which will invalidate the use.
Task 7.4. Clinical studies (Ni-Ti stent). These are human studies aiming at studying the effect of using the stent as markers on treatment endpoints for radiotherapy planning and delivery.
Deliverables (projected outcome)
D7.1. Improved target localization using the stent to combine CT and MR images.
D7.2. Improved target localization during delivery of radiotherapy.
D7.3. Stent may be feasible of online tracking of the marker.
D7 4. Stent may improve urination and prevent obstruction of bladder outlet.
D7.5. Improved precision of dose delivery in 3D MRI guided brachytherapy.